Effect of perioperative regional intraperitoneal chemotherapy on postoperative recurrence of advanced gastric cancer
10.3760/cma.j.issn.1673-4904.2014.17.018
- VernacularTitle:围手术期腹腔区域化疗对晚期胃癌复发的影响
- Author:
Shifu WANG
;
Bin LUO
;
Fuzheng TAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Recurrences;
Perioperative period;
Regional intraperitoneal chemotherapy
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(17):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of perioperative regional intra peritoneal chemotherapy on postoperative recurrence of advanced gastric cancer.Methods Eighty-six patients with advanced gastric cancer were divided into observation group (44 patients) and control group (42 patients) according to the aspiration of patients.All patients received 2-4 cycles of chemotherapy of PCF regimen before and after surgical treatment.Observation group was combined with perioperative regional intraperitoneal chemotherapy,and control group only received surgical treatment.The treatment effectiveness and the status of postoperative recurrence were compared between two groups.Results The response rate of control group and observation group were 76.2％ (34/42) and 93.2％ (41/44),respectively.There was significant difference (P ＜ 0.05).The adverse effect of the two groups were gastrointestinal adverse reaction and myelosuppression.There was no significant difference between two groups (P＞ 0.05).After followed up for 3-36 months,6 patients in observation group occurred recurrence,and 14 patients in control group occurred recurrence.The long-term recurrence rate (＞ 24 months) between two groups had significant difference (P ＜ 0.05).Conclusion Perioperative regional intraperitoneal chemotherapy has better effectiveness on inhibiting the postoperative recurrence of advanced gastric cancer.
