High Sensitivity CRP, Fibrinogen and Homocysteine in Relation to Carotid Intima-media Thickness in Acute Ischemic Stroke.
- Author:
Won Goo LEE
1
;
Kwangsoo KIM
Author Information
1. Department of Neurology, Kosin University College of Medicine, Busan, Korea. nekim@ns.kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Acute ischemic stroke;
Carotid intima-media thickness;
Fibrinogen;
High sensitivity C-reactive protein;
Homocysteine
- MeSH:
Atherosclerosis;
C-Reactive Protein;
Carotid Intima-Media Thickness;
Cerebral Infarction;
Fibrinogen;
Homocysteine;
Humans;
Immunoassay;
Luminescence;
Stroke
- From:Kosin Medical Journal
2011;26(2):149-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the relationship of high sensitivity C-reactive protein (hs-CRP), fibrinogen and homocysteine to carotid intima-media thickness (IMT) in acute ischemic stroke. METHODS: Subjects were 347 patients with acute cerebral infarction. The carotid arterial wall thickness was measured using high resolution B-mode ultrasound. The serum levels of hs-CRP, fibrinogen and homocysteine were measured by latex-enhanced turbidimetric immunoassay, clot scattering method, and chemiluminescence immunoassay respectively. Univariate regression analysis was performed to evaluate the relationship between these levels and carotid IMT. RESULTS: In patients with acute ischemic stroke, carotid IMT was significantly correlated with increased serum levels of hs-CRP and fibrinogen (P < 0.05, P < 0.01, respectively). However association between serum homocysteine and carotid IMT was not statistically significant. CONCLUSIONS: Increased serum levels of hs-CRP and fibrinogen may be correlated with carotid IMT. Measurement of serum hs-CRP and fibrinogen may be helpful for predicting degrees of atherosclerosis in acute ischemic stroke.
