The effect of early intravenous thrombolysis combined with atorvastatin in the treatment of acute myocardial infarction
10.3760/cma.j.issn.1673-4904.2014.16.004
- VernacularTitle:早期静脉溶栓联合阿托伐他汀对急性心肌梗死的干预效果
- Author:
Shujun JIANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Treatment outcome;
Early intravenous thrombolysis;
Atorvastatin
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(16):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effect of early intravenous thrombolysis combined with atorvastatin in the treatment of acute myocardial infarction.Methods Seventy-two patients with acute myocardial infarction from March 2011 to March 2012 were divided into experimental group and control group by random number table method,with 36 cases in each.Experimental group was given early intravenous thrombolysis combined with atorvastatin treatment,and control group was given atorvastatin treatment.The effects in 2 groups was observed.Results The recanalization rate in experimental group was significantly higher than that in control group [80.6％ (29/36) vs.52.8％ (19/36)],and the incidence of post infarction angina,heart failure and reperfusion arrhythmia were significantly lower than those in control group [11.1％(4/36) vs.27.8％(10/36),8.3％(3/36) vs.25.0％(9/36),44.4％(16/36) vs.72.2％(26/36)],there were significant differences(P＜ 0.05).The leukocyte differentiation antigen,matrix metalloproteinases and C reactive protein between 2 groups before treatment had no significant difference (P ＞ 0.05),but those indexes after treatment were obviously improved,the improvement in experimental group was better than that in control group,there was significant difference (P ＜0.05).The United States National Institutes of Health Stroke Scale (NIHSS) score between 2 groups before treatment had no significant difference (P ＞ 0.05),the NIHSS score after treatment in experimental group was better than that in control group [(4.2 ± 3.7) scores vs.(7.9 ± 4.1) scores] (P ＜ 0.05).The proportion of mRS score 0-1 after 3 months of treatment in experimental group was higher than that in control group [52.8％(19/36) vs.33.3％(12/36)],the proportion of 2-6 scores was lower than that in control group [47.2％ (17/36) vs.66.7％ (24/36)] (P ＜0.05).Conclusion Early intravenous thrombolysis combined with atorvastatin has obviously curative effect in the treatment of acute myocardial infarction and has some clinical value.
