Nursing study on allogenic bone marrow mesenchymal stem cell transplantation in patients with HBV related acute-on-chronic liver failure
10.3760/cma.j.issn.1672-7088.2014.18.001
- VernacularTitle:慢加急性乙型肝炎肝衰竭患者行异体骨髓间充质干细胞移植的护理
- Author:
Feifei CHEN
;
Lihua YANG
;
Yuanli CHEN
;
Junfeng CHEN
;
Yinke CAI
- Publication Type:Journal Article
- Keywords:
Allogenic bone marrow stem cell transplantation;
Acute-on-chronic liver failure;
Hepatitis B;
Nursing
- From:
Chinese Journal of Practical Nursing
2014;30(18):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective Our research aimed to investigate the efficacy and the nursing characteristics of allogenic bone marrow mesenchymal stem cell (BM-MSCs) transplantation in HBV related acute-on-chronic liver failure (ACLF) patients.Methods A total of 91 HBV related ACLF patients were enrolled,among whom 45 patients received allogenic BM-MSCs transplantation via peripheral vein and other 46 patients received medical treatment only.We assessed the 12-week survival rates and the variation of model for end liver disease (MELD) score.Besides,we administrated comprehensive nursing for these patients in different stages of the transplantation.Results The cumulated survival of patients received BM-MSC transplantation was 75.6％,which was higher than the control group (54.5％).The level of total bilirubin and International Normalized Ratio (INR) had greatly improved.41 of 45 patients passed through perioperative period safely,without any severe adverse events.11 patients died due to exacerbation of liver failure,among whom 3 happened in perioperative period.But none was related with the operation.Conclusions Allogenic BM-MSCs transplantation can improve the survival rate of HBV related ACLF patients.The psychological nursing pre-operation,skilled operation,intensive care and observation post operation were beneficial to the patients' recovery after transplantation.
