Effects of subcutaneous injection duration of heparin on side effects: A Meta-analysis
10.3760/cma.j.issn.1672-7088.2014.18.019
- VernacularTitle:低分子肝素皮下注射持续时间对不良反应影响的Meta分析
- Author:
Yanling LI
;
Bin ZHAO
;
Huimin LIU
- Publication Type:Journal Article
- Keywords:
Low molecular weight heparin;
Subcutaneous injection;
Injection duration;
Meta-analysis
- From:
Chinese Journal of Practical Nursing
2014;30(18):59-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of injection duration on bruising and pain after the subcutaneous injection of heparin.Methods The relevant randomized controlled trials,quasi-randomized controlled trials about subcutaneous heparin injection duration of ≥30 s and ≤ 10 s were searched in the databases of CNKI,CBM,VIP Database for Chinese Technical Periodicals,PubMed,Highwire,ScienceDirect,Chinese Cochrane Library,Wanfang database and Google.The quality of RCTs was assessed and Metaanalysis was conducted by RevMan 5.0 Software.Results Twelve RCTs involving 1 986 injections were included.The results of Meta-analysis showed that:There was significant difference between the two groups in the occurrence of bruising.The injection duration of 30 s was much better to prevent bruising.Statistical differences existed in pain intensity between the two groups.Conclusions Prolonging the injection duration to 30 s may reduce the occurrence of subcutaneous bruising.There is no enough evidence to draw a conclusion on pain intensity.Adequately,the current study is limited to a small sample,powered and high quality randomized controlled trials are still needed to be conducted.
