Clinical effects of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: a Meta-analysis

VernacularTitle:保守治疗对比手术治疗急性非复杂性阑尾炎的临床疗效的Meta分析
Author: Liang FU ; Tao SUO ; Yu ZHANG ; Chao LU ; Lujun SONG
Publication Type:Journal Article
Keywords: Appendicitis; Anti-bacterial agents; Appendectomy; Treatment outcome; Meta-analysis
From: International Journal of Surgery 2014;41(5):300-304
CountryChina
Language:Chinese
Abstract: Objective To compare clinical effects of appendicectomy and conservative treatment of uncomplicated acute appendicitis.Methods Searched The Cochrane library,Medline,Pubmed,Embase,CBM,CNKI,VIP and Wan Fang database in any language.RCTs that compared conservative treatment with appendicectomy in patients with uncomplicated acute appendicitis were included from January 1983 to May 2013 and qualities of the trials were evaluated.Statistic analyses were carried out using RevMan 5.1 soft-ware.Results Four randomized trials met our inclusion criteria (821partiCI:pants).Antibiotics compared with appendicectomy resulted in similar outcomes with regards to the incidence of complicated appendicitis (RR:0.89,95％ CI:0.29-2.68) and intra-abdominal infection(RR:0.54,95％ CI:0.13-2.35).Antibiotics carries a lower risk of complications (RR 0.46,95％ CI:0.32-0.67),but requires more length of hospital stay (Mean Difference 0.52,95％ CI:0.16-0.88).Conclusions The effect of conservative treatment is safe and effective.But the recurrent uncomplicated appendicitis recommends operation.