Research progress on novel pathways and molecular targets for the treatment of sarcoma
10.3760/cma.j.issn.1673-4203.2014.05.017
- VernacularTitle:肉瘤治疗的新途径及分子靶点研究进展
- Author:
Zhifeng JIA
;
Yaheng ZHAO
;
Xiaoyi SHI
;
Jiangang FENG
- Publication Type:Journal Article
- Keywords:
Sarcoma;
Treatment,outcome;
Molecular target;
Review
- From:
International Journal of Surgery
2014;41(5):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Sarcomas collectively represent over 100 different subtypes of bone and soft tissue tumors.They are not sensitive to chemotherapy,which requires the development of tissue-specific or pathway-specific therapies.As our understanding of the molecular mechanisms driving sarcomas is rapidly advancing,the number of targeted therapies is also increasing.Recently identified novel druggable targets including the MDM2 amplifications in welldifferentiated and dedifferentiated liposarcomas,the fusion NAB2:STAT6 of solitary fibrous tumor,the SDH mutations in gastrointestinal stro mal tumors,the suppression of Mcl1 in synovial sarcomas,CDK4 in alveolar rhabdomyosarcoma.They will play an important role in the treatment of sarcoma.Here,the author do an overview of these factors.
