Correlation between serum homocysteine levels and large artery atherosclerotic stroke: a retrospective case series study
10.3760/cma.j.issn.1673-4165.2014.04.004
- VernacularTitle:血浆高半胱氨酸水平与大动脉粥样硬化性卒中的相关性:回顾性病例系列研究
- Author:
Fang YE
;
Jie YANG
;
Xin ZHANG
;
Fuqiang GUO
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Homocysteine;
Atherosclerosis;
Ultrasonography;
Magnetic Resonance Imaging;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2014;22(4):274-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum homocysteine (Hcy) and large artery atherosclerosis (LAA).Medods The consecutive stroke patients with LAA and small artery occlusion (SAO) were enrolled.The demographics,baseline clinical data,and laboratory test results were compared.Multivariate logistic regression analysis was used to identify the independent risk factors for LAA.Spearman correlation analysis was used to analyze the correlation between serum Hcy concentration and carotid plaque scores.Results A total of 117 patients with LAA and SAO were enrolled,42 were in the LAA group and 75 were in the SAO group.The plasma Hcy levels (median [interquartile range] 15.35 [12.20-20.43] μmol/Lvs.12.40 [10.40-15.00] μmoFL; Z=-2.540,P=0.011),the carotid plaque scores (6.30 ±4.11 mm vs.4.19 ±2.84 mm; t =2.952,P=0.004),and the proportion of plasma Hcy level at tertile groups of the patients (x2 =10.697,P =0.005) of the LAA plasma group were all significantly higher than those of the SAO group.Multivariate logistic regression analysis showed that the plasma Hcy concentration was in the third tertile (＞ 15.3 μmol/L),and it was an independent risk factor for LAA (odds ratio 4.739,95％ confidence interval 1.696-13.241; P =0.003).Moreover,there was a significant positive correlation between the serum Hcy concentration and the carotid plaque scores (r =0.245,P =0.008).Conclusions The plasma Hcy levels were positively correlated with the severity of carotid atherosclerosis.The Hcy ＞ 15.3 μmol/L was an independent risk factor for LAA.
