The role of matrix metalloproteinases in vascular inflammation
10.3760/cma.j.issn.1673-4408.2014.03.010
- VernacularTitle:基质金属蛋白酶在血管炎症中的作用
- Author:
Xue ZHOU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase;
Vascular inflammation
- From:
International Journal of Pediatrics
2014;41(3):253-256
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMP),which are secreted by a variety of cell types,have the function of degrading extracellular matrix.Based on the substrate specificity,MMP can be assigned to five subgroups:interstitial collagenases,gelatinases,stromelysins,membrane-type MMP and others.MMP have been implicated in the pathophysiologic processes of tumor invasion and metastasis,angiogenesis,cardiovascular disease,etc.And emerging evidences have shown that MMP play important roles in vascular inflammation.
