Lipoprotein (a) and the evaluation of cardiovascular disease risk

VernacularTitle:脂蛋白(a)与心血管病风险评估
Author: Lieying FAN ; Lishan SUN
Publication Type:Journal Article
Keywords: Lipoprotein(a); Cardiovascular diseases; Risk factors
From: Chinese Journal of Laboratory Medicine 2014;37(7):505-508
CountryChina
Language:Chinese
Abstract: Lipoprotein (a) [Lp (a)] is an LDL-like molecule consisting of an apolipoprotein (B) [Apo (B)] particle attached by a disulphide bridge to apolipoprotein (a) [Apo (a)].Because of the LPA gene polymorphisms,there exists Lp (a) molecular heterogeneity in the human population.Recently,several observations have pointed out that elevated serum Lp (a) levels may be an independent risk factor of cardiovascular disease and an predictive indicator of cardiovascular disease.Recent findings suggest that Lp (a)-lowering therapy might be beneficial in patients with high Lp(a) levels.Currently,there are some problems in Lp(a) assay,including clinically diverse methods,the Lp (a) molecular heterogeneity between reference materials and test samples.Standardization of the Lp (a) reference reagents and measurement methods may be helpful for the wide application of Lp(a) in clinical medicine and be helpful for assuring the role of Lp(a) as an independent risk factor and predictive indicator of cardiovascular diseases.