Clinical studies of the low-intensity anticoagulation of Warfarin after heart valve replacement
10.3760/cma.j.issn.1001-4497.2014.06.012
- VernacularTitle:心脏瓣膜置换术后华法林低强度抗凝的随访研究
- Author:
Tianyi WANG
;
Ping XU
;
Hongbo GAO
;
Zhenfu LI
;
Sumin YANG
;
Qiang HUANG
;
Qing CHANG
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis implantation;
Warfarin;
Anticoagulation intensity
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2014;30(6):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the necessity of low-intensity anticoagulation standard in patients after heart valve replacement and the rationality of INR in our hospital.Methods 681 eligible candidates were anticoagulated under the current guidelines for postoperative anticoagulation therapy in our hospital(AVR 1.5-2.0,MVR 2.0-2.5,DVR 2.0-2.5,TVR 2.5-3.0).We monitored the patient 's PT regularly and analyzed the occurrence of anticoagulation-related complications,such as bleeding,thrombosis and embolism.Results 602 cases completed the follow-up.During the period of follow-up,66 patients had bleeding tendencies,the incidence of bleeding complications was 10.96％ (66/602).1 1 patients had embolism complications,the incidence of thrombotic complications was 1.83 ％ (11/602).The average of INR was 2.24± 0.68,the mean oral Warfarin dose was(3.12± 1.14) mg/d.Conclusion Our study suggest that the effect of low-intensity anticoagulation after heart valve replacement is reliable.Further more,the current anticoagulation standards of our hospital meet the requirements of postoperative clinical anticoagulant after heart valve replacement in our region.
