The correlation of distal latency and esophageal motility under esophageal high resolution manometry in gastroesophageal reflux disease
10.3760/cma.j.issn.1007-5232.2014.06.002
- VernacularTitle:高分辨率食管测压下胃食管反流病吞咽延迟时间与食管动力的相关性研究
- Author:
Di CHEN
;
Hui WANG
;
Ling ZHANG
;
Han LIN
;
Duowu ZOU
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux disease;
High resolution manometry;
Distal latency;
Esophageal motility
- From:
Chinese Journal of Digestive Endoscopy
2014;31(6):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between esophageal motility and distal latency (DL) in gastroesophageal reflux disease (GERD) using high resolution manometry (HRM).Methods A total of 51 GERD patients underwent HRM and 24 h-esophageal pH monitoring.According to the HRM topography (characterized as either break peristalsis or normal esophageal movement),all GERD patients were divided into two groups:hypomotility group (n =28) and normal group (n =23).Fourteen non-GERD controls were enrolled.The monitoring results were analyzed.Results The HRM DL of 28 esophageal hypomotility patients(54.9％,28/51) were the longest (7.27 ± 1.44) s.Patients with normal peristalsis also had longer latency (6.70 ± 1.41)s than the non-GERD controls (5.86 ± 0.96)s.All the differences were statistically significant (P ＜ 0.01).DCI of hypotensive peristalsis patients (712.49 ± 703.10) mmHg · s · cm was lower compared with the other groups [(1 285.85 ± 850.83) mmHg · s · cm,(1 109.74 ± 611.70) mmHg · s · cm] (P ＜0.O1).Other indicators such as LES pressure,CFV and IBP showed no significant differences among groups (P ＞ 0.05).Conclusion Esophageal manometry of GERD patients indicates that esophageal hypomotility is accompanied with prolonged DL.Because DL of all GERD sufferers are extended,esophageal dysmotility has great implications for GERD's development.
