One center's experience: survival analysis of 194 cases of liver transplantation for primary hepatocellular carcinoma
10.3760/cma j.issn.0254-1785.2014.06.005
- VernacularTitle:肝移植治疗原发性肝癌194例的临床效果分析及术后肿瘤复发的危险因素
- Author:
Jiabin ZHANG
;
Hui REN
;
Xu JI
;
Lin WANG
;
Min ZHANG
;
Hongbo WANG
;
Zhenwen LIU
- Publication Type:Journal Article
- Keywords:
Primary Hepatocellular Carcinoma;
Liver transplantation;
Survival analysis
- From:
Chinese Journal of Organ Transplantation
2014;35(6):337-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of orthotopic liver transplantation in the management of primary hepatocellular carcinoma (PHC) ; To evaluate the survival and prognostic factors of liver transplantation for PHC.Method The clinical data from 194 consecutive PHC patients who underwent OLT were retrospectively analyzed.Result The 1-,3-and 5-year cumulative survival rate of the 194 patients was 92.78％,78.07％ and 76.80％ respectively.There were 37 cases of recurrence or metastasis of the tumor with the incidence rate being 19.1％ (37/194).The tumor TNM stage (P=0.026 667),tumor diameter (P =0.0045),tumor number (P =0.0318),vascular invasion (P =0.006 059),and AFP level before transplantation (P =0.003 426) were significantly related with tumor recurrence.Multivariate analysis revealed that tumor diameter (P =0.0081,OR =0.789,95％ CI:2.1233-6.124),vascular invasion (P＜0.001,OR =5.928,95 ％ CI:1.173-86.789),and AFP level before transplantation (P =0.019,OR =2.601,95％ CI:2.196-5.658) were independent risk factors for tumor recurrence.There was statistically significant difference in survival rate and tumor-free survival rate between Milan criteria group and beyond-UCSF criteria group (P＜0.01),and between UCSF criteria group and beyond-UCSF criteria group (P＜0.01).There was no significant difference in survival rate and tumor-free survival rate between Milan criteria group and UCSF criteria group (P ＞0.05).Conclusion Liver transplantation is an effective treatment for PHC.The tumor diameter ＞8 cm,vascular invasion and AFP level significantly affect the survival of PHC patients.
