Application of metabonomics in cardiovascular pharmacology research
10.3867/j.issn.1000-3002.2014.03.022
- VernacularTitle:代谢组学在心血管药理学研究中的应用
- Author:
Huilin WANG
;
Jianping GAO
- Publication Type:Journal Article
- Keywords:
metabono mics;
cardiovascular disease
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(3):438-442
- CountryChina
- Language:Chinese
-
Abstract:
Metebonomics is a branch of system biology,which,based on group index analysis, aims to analyze low molecular weight metabolites of the body both qualitatively and quantitatively through high flux and data processing.In recent years,the application of metabonomics to research of cardio-vascular pharmacology has been attracing more attention.This paper,by researching do mestic and overseas literature,summarizes the applications of metabonomics in the prevention and treatment of co mmon cardiovascular diseases such as hypertension,hyperlipide mia,atherosclerosis and myocardial ische mia.Related pharmacological researches targeted at patients,ani mal models and cell models clas-sified.Evidence for evaluation of effects and mechanis ms of drugs is provided by analyzing the patterns of change of metabolites in the progression of diseases.Finally,meaningful biomarkers are proposed.
