The use of cadaveric donor liver with age above fifty in liver transplantation
10.3760/cma.j.issn.1007-631X.2014.06.010
- VernacularTitle:50岁以上的尸体供肝在肝移植中的应用
- Author:
Kai WANG
;
Hong ZHENG
;
Yonglin DENG
;
Cheng PAN
;
Wentao JIANG
;
Zhongyang SHEN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Graft survival
- From:
Chinese Journal of General Surgery
2014;29(6):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of aged cadaveric donor liver on long-term survival of liver transplant recipients.Methods Patients who underwent first time liver transplantation from cadaveric donor aging above 40 years were studied.Those patients were divided into donor age ＜ 50 group and age ≥ 50 group.Data for donor graft,recipient perioperative condition as well as long-term survival of recipients were compared between the two groups.Results There were 21 recipients receiving liver graft from a donor aging ≥ 50 (54.6-± 3.9) years.58 cases were given a liver graft from a donor aging ＜ 50 years (42.6 ± 2.9).The overall donor graft conditions were not different between the two groups (P ＞ 0.05).However,the median amount of operation time in donor age ≥50 group was longer than that in age ＜ 50 group (9.5 h vs.8.0 h,Z =-1.994,P =0.046).Median red blood cell (RBC) transfusion volume was greater in the age ≥50 group than that in age ＜50 group (1 000 ml vs.800 ml,Z =-2.593,P =0.010).During the follow-up,graft survival rates in 1,3 and 5 years were 74％,55％,55％ in donor age ≥50 group and 87％,66％,63％ in donor age ＜ 50 group,respectively (Z =0.903,P =0.342).Conclusions Use of aging cadaveric donor liver expandes donor pool,and is as well as safe,not hindering in graft's long term functions.
