The value of negative lymph node count in T3 gastric cancer
10.3760/cma.j.issn.1007-631X.2014.06.003
- VernacularTitle:阴性淋巴结数目在T3期胃癌预后中的价值
- Author:
Nan JIANG
;
Jingyu DENG
;
Xuewei DING
;
Honggen LIU
;
Jingli CUI
;
Xuguang JIAO
;
Han LIANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Lymph node excision;
Neoplasm metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
2014;29(6):412-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate negative lymph node count (NLNC) in prediction of prognosis of T3 gastric cancer after radical resection.Method 214 T3 patients of radical gastrectomy with complete clinical and follow-up data between Jan 2003 to Dec 2007 were enrolled.Survival was determined by the Kaplan-Metier method and univariate analysis was done by Log-rank test,Multivariate analysis was performed using the COX proportional hazard regression model.-2loglikelihood value and the hazard ratio (HR) value were used to compared the value of number of lymph node-negative (NLNC) staging and pN staging and lymph node metastasis rate (MLR) in gastric cancer prognosis evaluation.Results Univariate analysis showed that,pN stage (x2 =31.664),MLR stage (x2 =34.123),tumor size (x2 =5.025),type of differentiation (x2 =5.993),Borrmann classification (x2 =5.401),NLNC stage (x2 =37.256) were related to survival (P ＜ 0.05).COX multivariate analysis showed that-2loglikelihood of pN staging is 1 336.761,HR value is 1.464,-2loglikelihood value of MRL staging is 1 335.821,HR value is 1.441.-2loglikelihood value of NLNC staging is 1 326.902,HR value is 1.725.The N0 and N1 staging prognosis in different NLNC staging was significant (P =0.008,P =0.014).Conclusions Sufficient number of negative lymph node prolongs survival and reduces the risk of early recurrence in advanced gastric cancer.
