Effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice

VernacularTitle:慢性暴露于亚麻醉浓度七氟醚对小鼠记忆功能和内环境稳态的影响
Author: Liufang CHEN ; Quanyuan FU ; Jing WAN ; Zongze ZHANG ; Yanlin WANG ; Yun WU
Publication Type:Journal Article
Keywords: Anesthetics,inhalation; Occupational exposure; Memory; Homeostasis
From: Chinese Journal of Anesthesiology 2014;34(4):451-453
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of chronic exposure to sub-anesthetic concentrations of sevoflurane on memory function and homeostasis of mice.Methods Thirty-six healthy male Kunming mice,aged 40 days,weighing 25-30 g,were randomly assigned into 3 groups (n =12 each):control group (group C),0.1％ sevoflurane group (group L) and 0.5 ％ sevoflurane group (group H).The mice inhaled 0.1％ (group L) or 0.5％ sevoflurane (group H) between 18:00-6:00 (the next day) every night for 30 days.Water maze test was performed at 27-30 days of inhalation.Blood samples were collected from the left ventricle for blood gas analysis and for determination of blood electrolytes.Results There was no significant difference in swimming time in Water maze test,number of errors and blood gas analysis and blood electrolytes.Conclusion Chronic exposure to subanesthetic concentrations of sevoflurane has no significant effects on memory function and homeostasis of mice.