Clinical significance of serum high sensitive C-reactive protein in patients undergone prostate biopsy
10.3760/cma.j.issn.1000-6702.2014.06.017
- VernacularTitle:前列腺穿刺活检患者中血清高敏C反应蛋白测定的临床意义
- Author:
Xiaodong MO
;
Xiaofeng CAI
;
Gang LI
;
Xuefeng ZHANG
;
Jing TANG
;
Jinxian PU
;
Jianquan HOU
- Publication Type:Journal Article
- Keywords:
High sensitive C-reactive protein;
Prostatic neoplasms;
Prostatic hyperplasia;
Prostate biopsy
- From:
Chinese Journal of Urology
2014;35(6):461-464
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical significance of serum high sensitive C-reactive protein (hs-CRP) in patients undergone prostate biopsy.Methods A total of 273 consecutive patients were enrolled,aged 44-95 years (mean,69 years).All the patients underwent prostate biopsy.The pathological findings showed 96 cases with prostate cancer (PCa) and 177 cases with benign prostate hyperplasia (BPH).The difference of hs-CRP level between patients with PCa and those with BPH was analyzed.The positive prostate biopsy rate was compared between the patients with high hs-CRP level and those with normal hs-CRP level.Logistic regression was used to evaluate the effect of factors such as hs-CRP,tPSA,PSA density,prostate volume and age on prostate biopsy.Results The medians (interquartile range) of hs-CRP were 3.22 mg/L (1.22-9.84 mg/L) in patients with PCa and 1.24 mg/L (0.55-2.76 mg/L) in those with BPH,respectively,with significant difference(P＜0.05).The positive prostate biopsy rate in patients with high hs-CRP (＞ 3 mg/L)was 55％ (51/92),higher than that in those with normal hs-CRP (≤ 3 mg/L).The odds ratio of hs-CRP was larger than that of all other factors analyzed including tPSA,prostate volume and age according to the Logistic regression analysis.Conclusions Elevated serum hs-CRP level is associated with increased positive prostate biopsy.Serum hs-CRP acts as an independent factor increasing the positive prostate biopsy rate in patients undergone prostate biopsy.
