Salvianolic acid B in vitro inhibited matrix metalloproteinases-1, -2, and -9 activities.
- Author:
Yahui LIANG
;
Ping LI
;
Qifu HUANG
;
Jingxia ZHAO
;
Xin LIU
;
Miaoke DAI
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2009;7(2):145-50
- CountryChina
- Language:English
-
Abstract:
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which as a group can degrade essentially all extracellular matrix components. The proteolytic property of the MMPs is important during wound healing to remove debris and facilitate cell migration. Targeting towards the decreased MMPs activities is a new treatment strategy for healing chronic wounds. Salvia miltiorrhiza is a popular Chinese herb that could promote chronic ulcers healing for topical use. Salvianolic acid B (Sal B) is the most abundant bioactive component in Salvia miltiorrhiza. The research was designed to explore the inhibitory effects of Sal B on MMP-1, MMP-2 and MMP-9 activities.
