Sub-acute toxicity of trifluoromethylhydroartemisinin (BB101) in monkeys
- Author:
Truong Van Nhu
- Publication Type:Journal Article
- Keywords:
Drug
- MeSH:
Toxicity;
animals;
Haplorhini;
Artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;0(6):44-49
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
At the dose of 4 and 8 mg/kg/day for 30 consecutive days, the monkeys appeared to have normal living actions taking meals and drink. Their body weights did not change significantly. At the dose of 4mg/kg/day for 30 consecutive days, changes of SGOT and creatinine indices were not significant but erythrocyte, reticulocyte, leucocyte and SGPT indices changed significantly. These indices became normal 15 days after interruption of the drug administration. At the dose of 8 mg/kg/day for consecutive 30 days, the changes of SGOT index was not significant during the administration. Haemoglobin, erythrocyte, reticulocyte, leucocyte, SGPT and creatinine indices were significantly changed during the 30 days administration. Haemoglobin, erythrocyte, reticulocyte, SGPT and creatinine indices changed significantly but erythrocyte and leucocyte indices became normal 15 days after the drug administration
