Influence of Shenqi Recipe on mesangial cells and interstitial fibroblasts of chronic renal failure rats
- Author:
Jing MU
;
Yikui LI
;
Shengguang FU
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2003;1(2):122-4
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effect of Shenqi Recipe on the proliferation of glomerular mesangial cells (MC) and interstitial fibroblasts (FC) in rats. METHODS: The effect of serum containing prepared drugs from normal and chronic renal failure rats treated by Shenqi Recipe on glomerular mesangial cells and intersititial fibroblasts in vitro was observed by MTT colorimetric assay and serophrmacology. RESULTS: Compared with the blank sample normal rats, serum containing Shenqi Recipe inhibited the proliferation of MC and FC (P<0.001), and the serum containing Shenqi Recipe of CRF rats had significantly inhibited the proliferation of MC and FC compared with the model group(P<0.001). Conclusion Shenqi Recipe can postpone CRF progress by this mechanism.
