Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer
- Author:
Zhe CHEN
;
Xiaofeng ZHAI
;
Yonghua SU
;
Xuying WAN
;
Jin LI
;
Juemin XIE
;
Bo GAO
- Publication Type:Clinical Trial
- From:
Journal of Integrative Medicine
2003;1(3):184-6
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer (PLC). METHODS: One hundred patients with moderate and advanced PLC were randomly divided into cino-treated group (50 patients) and control group (50 patients). The quality of life, tumor size, some changes of laboratory tests, and survival time were observed. RESULTS: The progressive rate of cino-treated group (18%) was lower than that of the control group (32%). The quality of life of the cino-treated group (80%) was better than that of the control group (72%), but without statistical significance. The survival rate of >12 months of the cino-treated group (30%) was higher than that of the control group (18%). The patients' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group. The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group. CONCLUSION: Cinobufacini injection can not only inhibit the proliferation of cancer, but also protect liver function, improve quality of life and prolong survival time.