T Cell Activation in Ischemic Heart Disease.
10.4070/kcj.1996.26.3.645
- Author:
Seung Ho HUR
;
Kee Sik KIM
;
Seong Wook HAN
;
Kyung Mok SHIN
;
Yoon Nyun KIM
;
Kwon Bae KIM
- Publication Type:Original Article
- Keywords:
Soluble interleukin 2 receptor(sIL-2R);
T cell activation
- MeSH:
Angina, Stable;
Angina, Unstable;
Atherosclerosis;
Coronary Angiography;
Coronary Vessels;
Diagnosis;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Interleukin-2;
Lymphocyte Activation;
Lymphocytes;
Male;
Myocardial Ischemia*;
Plaque, Atherosclerotic;
Receptors, Interleukin-2;
T-Lymphocytes
- From:Korean Circulation Journal
1996;26(3):645-650
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It was recently shown that human atherosclerotic plaque contains large numbers of T lymphocytes : this indicates that immune and inflammatory mechanism may be important factors in the pathogenesis of atherosclerosis. By measuring the soluble interleukin 2 receptor(sIL-2R) level we can evaluate the activation of T lymphocyte. The purpose of this study is to evaluate relationship between T cell activation and ischemic heart disease by measuring the soluble interleukin 2 receptor (sIL-2R) level in patient with ischemic heart disease. METHOD: Seventy-two patients(40 males and 32 female, mean age : 56.5+/-9.9 years) who were taken coronary angiography were included in this study. Among them, 49 patients showed abnormal coronary angiographic findings and 23 patients showed normal coronary angiographic findings. Ten mililiters of arterial blood was drawn at the time of coronary angiography. The blood was allowed to coagulate and then the serum was removed and tested in duplicate for soluble interleukin 2 receptor (sIL-2R) level by ELISA. RESULTS: 1) The soluble interleukin 2 receptor (sIL-2R) level was significantly different between abnormal coronary angiographic findings and normal coronary angiographic findings (P < 0.001). 2) According to clinical severity of ischemic heart disease (i.e. stable angina, unstable angina, acute myocardial infarction.), soluble interleukin 2 receptor (sIL-2R) level was not significantly different between single vessel disease group and multivessels disease groups (p > 0.05), but showed increasing tendency with clinical severity. 3) According to numbers of involved coronary vessels, soluble interleukin 2 receptor (sIL-2R) level was not significantly different between single vessel disease group and multivessels disease groups (p > 0.05). CONCLUSION: T lymphocyte activation, as reflected in elevated soluble interlekin 2 receptor (sIL-2R) level, is frequent in patient with ischemic heart disease. In the further we will investigate relationship between clinical diagnosis of ischemic heart disease of the numbers of involved coronary vessels and T cell activation.
