Effects of Shengqing Capsules on cholelithiasis-related genes in guinea pigs
- Author:
Peiting ZHU
;
Jingzhe ZHANG
;
Xuelin ZHANG
;
Zuobiao YUAN
;
Hongying ZHANG
;
Ju GAO
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2005;3(3):207-10
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the molecular mechanisms of Shengqing Capsules in treating cholelithiasis. METHODS: Sixty female guinea pigs were randomized into 3 groups: group I (fed with normal diet), group II (fed with low-protein diet) and group III (fed with low-protein diet and Shengqing Capsules). After six-week feeding, the gallstone formation and the expressions of bilirubin UDP-glucuronosyltransferase (B-UGT) mRNA and cholesterol 7alpha-hydroxylase (CYP7A1) mRNA were observed. RESULTS: The proportions of stone-formed in groups I, II and III were 2/14, 9/12 and 4/14, respectively. There were significant differences among the three groups (P<0.05). The expressions of B-UGT and CYP7A1 mRNAs were higher in both group I and group III as compared with those in the group II (P<0.05). CONCLUSION: Shengqing Capsules can reduce the rate of stone-formation, which may be due to its interference of metabolism of bilirubin and cholesterol and up-regulation of the expressions of B-UGT and CYP7A1 mRNAs.
