Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats
- Author:
Lan LUO
;
Huijun YIN
;
Ying ZHANG
;
Yuerong JIANG
;
Ying LIU
;
Dazhuo SHI
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2005;3(6):463-5
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats. METHODS: An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique. RESULTS: The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated groupìthe parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01). CONCLUSION: GFS can improve experimental insulin resistance in rats.
