Tumor inhibiting and immunoloregulation effects of Mylabris Mixture on H22 cancer-bearing mice
- Author:
Agao ZHOU
;
Yong ZHANG
;
Deyun KONG
;
Yin WANG
;
Huizhen ZHANG
;
Shujun WANG
;
Gang KUI
;
Sheng HONG
;
Hailiang GE
;
Qiuhua REN
;
Xuming MAO
;
Jiarong DONG
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2006;4(5):504-8
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the mechanisms of tumor inhibiting and immunoloregulation of Mylabris Mixture on H22 cancer-bearing mice. METHODS: H22 cancer-bearing mice were chosen to observe the effects of tumor inhibiting and detect the proliferation function of T lymphocytes, the toxicity function of NK cells, the changes of T lymphocytes and the contents of interferon-gamma and interleukin-4. RESULTS: Mylabris Mixture could obviously inhibit the growth of H22 cancer in mice, and the tumor inhibition rat was 65.76%. The stimulation index of T lymphocyte transformation and percentage of NK cells in Mylabris Mixture-treated group were obviously higher than those in the normal control group. The subpopulation proportion of T lymphocytes in Mylabris Mixture-treated group was changed more than the normal control group. The production of interferon-gamma and interleukin-4 by T lymphocytes obviously increased in Mylabris Mixture-treated group (P<0.05, P<0.001). CONCLUSION: Mylabris Mixture has the effect of inhibiting the growth of tumor constitution, and regulating immunological function on mice with tumor. Its mechanisms include the reinforcement of T lymphocyte immune function, NK cell killing function and humoral immune function.
