Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice
- Author:
Peifeng CHEN
;
Luming LIU
;
Zhen CHEN
;
Shengyou LIN
;
Weixiang SONG
;
Yingfei XU
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2006;4(5):500-3
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma. METHODS: B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively. RESULTS: The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05 or P<0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the NS-treated group (P<0.01). CONCLUSION: The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
