Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats
- Author:
Hongwei GU
;
Zhaohui NI
;
Leyi GU
;
Yucheng YAN
;
Huili DAI
;
Ningli LI
;
Minfang ZHANG
;
Jiaqi QIAN
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2007;5(5):536-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the expression of angiopoietin receptor Tie-2 in the renal tissue of diabetic rats and the effects of Astragalus. METHODS: SD rats were randomly divided into normal control group, diabetes group and Astragalus-treated group. The expression of receptor Tie-2 in the renal tissue was assessed by using real-time quantitative polymerase chain reaction and immunohistochemical method. RESULTS: Glomerule Tie-2 protein expression was significantly elevated in the diabetes group as compared with the normal control group (P<0.01). Glomerule Tie-2 protein expression in the Astragalus-treated group was decreased as compared with the diabetes group (P<0.01). CONCLUSION: Tie-2 may play an important role in the pathogenesis of the early stage diabetic renal injury. The reno-protection effect of Astragalus may be mediated by down-regulating the expression of Tie-2 in the kidney tissue of diabetic rats.
