Matrine and anti-tumor drugs in inhibiting the growth of human lung cancer cell line
- Author:
Muyun ZHU
;
Zhenghua JIANG
;
Yuanwen LU
;
Yuan GUO
;
Junji GAN
- Publication Type:Journal Article
- From:
Journal of Integrative Medicine
2008;6(2):163-5
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the activities of matrine and anti-tumor drugs on SPCA/I human lung adenocarcinoma cell line. METHODS: Suppression effects of different concentrations of matrine and matrine combined with anti-tumor drugs on lung cancer cells were measured by methyl thiazolyl tetrazolium (MTT) colorimetric assay. RESULTS: Different concentrations of matrine could inhibit the growth of SPCA/I human lung adenocarcinoma cells and there was a positive correlation between the inhibition rate and the drug concentration. Different concentrations of matrine combined with anti-tumor drugs had higher growth inhibition rate than anti-tumor drugs alone. CONCLUSION: Matrine has direct growth suppression effect on SPCA/I human lung adenocarcinoma cells and matrine combined with anti-tumor drugs shows a significant synergistic effect on tumor cells.
