Comparison of Ferucarbotran-Enhanced MRI and Triple-Phase MDCT for the Detection of Hepatocellular Carcinoma in Advanced Liver Cirrhosis.
10.3348/jkrs.2008.58.1.53
- Author:
Yong Hwan JEON
1
;
Seung Hoon KIM
;
Dongil CHOI
;
Min Ju KIM
;
Sam Soo KIM
;
Jiwon LEE
;
Heon HAN
;
Jongmee LEE
Author Information
1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. shkim@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, hepatocellular;
Liver cirrhosis;
Magnetic resonance (MR);
Tomography, spiral computed;
Ferumoxides
- MeSH:
Carcinoma, Hepatocellular;
Dextrans;
Humans;
Liver;
Liver Cirrhosis;
Liver Transplantation;
Magnetite Nanoparticles;
ROC Curve;
Tomography, Spiral Computed
- From:Journal of the Korean Radiological Society
2008;58(1):53-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare the diagnostic performance of ferucarbotran-enhanced MRI at 1.5-T with triple-phase multidetector-row helical CT (MDCT) to detect hepatocellular carcinoma in patients with advanced liver cirrhosis. MATERIALS AND METHODS: Twenty patients with advanced liver cirrhosis (Child's class B:C = 8:12) underwent ferucarbotran-enhanced MRI and triple-phase MDCT prior to liver transplantation. The mean time interval between the two imaging techniques was 18 days (range, 1-35 days). Three radiologists independently reviewed both images on a lesion-by-lesion basis and interpreted them for comparison with the pathologic findings of the explanted livers. As well, the sensitivity and an alternative-free response receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance of each technique. RESULTS: The mean area under the ROC curve (Az) was significantly higher for the triple-phase MDCT (0.766) compared to the ferucarbotran-enhanced MRI (0.675) (p < 0.001). Similarly, the mean sensitivity of the triple-phase MDCT (60.3%) exceeded the ferucarbotran-enhanced MRI (43.1%). The results indicate that the triple-phase MDCT provides significantly greater mean sensitivity than the ferucarbotran-enhanced MRI (p < 0.001). CONCLUSION: The triple-phase MDCT provided a better diagnostic performance and higher sensitivity than the ferucarbotran-enhanced MRI for the detection of hepatocellular carcinomas in patients with advanced liver cirrhosis.
