An overview of glycoconjugates for cancer targeting therapy and diagnosis.
- Author:
Weiqin WANG
;
Zhenhai ZHANG
;
Jianping ZHOU
;
Hui PANG
;
Huixia Lü
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2013;48(12):1763-70
- CountryChina
- Language:Chinese
-
Abstract:
Because of the changed metabolic behaviors of cancer cells, tumor cells uptake a corresponding larger amount of glucose in physiological condition when compared with normal cells. And they were prone to metabolize glucose for generating energy in anaerobic glycolysis ways in order to grow quickly. Anaerobic glycolysis consumes more glucose than aerobic way when the same amount of energy is obtained, which also results in large demand of glucose in tumor cells. This review briefly describes therapy methods related to characteristic mentioned above, and summarizes the research progress of drugs, diagnostic reagents and carriers conjugated with glucose, glucose derivatives or other kinds of sugars for cancer targeting. Furthermore, typically relative research reports from 2012 till now were listed and analyzed.
