Cyclin D1 Expression and Patient Outcome After Tamoxifen Therapy in Estrogen Receptor Positive Breast Cancer.
10.4048/jkbcs.2000.3.1.51
- Author:
Sehwan HAN
1
;
Hong Yong KIM
;
Kyeongmee PARK
;
Byung Noh BAE
;
Ki Hwan KIM
;
Hong Joo KIM
;
Young Duck KIM
;
Young Jin YUH
;
Sung Rok KIM
Author Information
1. Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Differentiation;
Myc;
p27kip1;
Prognosis;
Treatment
- MeSH:
Breast Neoplasms*;
Breast*;
Cell Cycle;
Cell Differentiation;
Cyclin D1*;
Cyclins*;
Disease-Free Survival;
Estrogens*;
Humans;
Prognosis;
Tamoxifen*
- From:Journal of Korean Breast Cancer Society
2000;3(1):51-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Cyclin D1 expression is closely related with ER in breast cancer. We conducted this study to evaluate whether therapeutic response to tamoxifen is varied with levels of cyclin D1 expression in ER positive breast cancer patients. METHODS: Immunohistochemical assay for cyclin D1 protein was performed in 66 patients treated with tamoxifen for more than 2 year. Patient survival and correlation between cyclin D1 expression and biologic data of the patients were analyzed. RESULTS: Cyclin D1 expression was detected in 46 (69.7%) and significantly reduced in poorly differentiated cancer (p=0.023). Cyclin D1 expression was high in the tumors expressing Myc (15/15 vs. 31/51; p=0.002), and was markedly increased in the tumors in which p27Kip1 expression was repressed (30/38, 78.9%). However, the difference was not ststistically significant (p=0.051). There was no significant relationship between cyclin D1 expression and S-phase. Patients with tumors expressing cyclin D1 showed better disease free survival and overall survival but the difference was not statistically significant. CONCLUSIONS: Cyclin D1 expression was associated with cell differentiation bit not useful in discriminating high risk group with tamoxifen treatment. Cyclin D1 may have a role other than cell cycle regulator in ER positive breast cancer, such as differentiation signal.
