Advances in the study of aldehyde oxidases.
- Author:
Jiaqi MI
;
Yan LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2014;49(5):582-9
- CountryChina
- Language:Chinese
-
Abstract:
Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings. AOX was found to widely distribute with the individual differences in vivo and plays an important role in phase I metabolism of drugs and xenobiotics. The biological characteristics of AOX and its contributions in drug metabolism are introduced briefly in this review.
