Significance ofβ-tubulin Ⅲexpression in the neoadjuvant chemotherapy of locally advanced cervical carcinoma
10.3760/cma.j.issn.1008-1372.2014.04.014
- VernacularTitle:β-tubulin Ⅲ的表达在局部晚期宫颈癌新辅助化疗中的意义
- Author:
Pei DU
;
Xiaowei ZHANG
;
Liquan CHEN
;
Guoqin CHEN
- Publication Type:Journal Article
- Keywords:
Tubulin/metabolism;
Uterine cervical neoplasms/pathology;
Uterine cervical neoplasms/drug therapy;
Chemo-therapy,adjuvant
- From:
Journal of Chinese Physician
2014;(4):475-478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the β-tubulin Ⅲexpression in locally advanced cervical cancers and its significance in the neoadjuvant chemotherapy of cervical cancer .Methods Immunohistochemistry was used to detect the expression of β-tubulin Ⅲin tissue samples from 62 cases of locally advanced cervical cancer patients .Groups paclitaxel +cisplatin/carboplatin (TP) (34 pa-tients) underwent two cycles of TP chemotherapy ,while group 5-fluorouracil+cisplatin(PF) (28 patients) underwent two cycles of PF chemotherapy .Comprehensive analysis of β-tubulinⅢexpressions of TP and PF neoadjuvant chemotherapies revealed the efficien -cy and operation rate .Results The positive rate ofβ-tubulin Ⅲ was 62.90% in locally advanced cervical cancer .β-tubulin Ⅲ ex-pression was not correlated with clinicopathological features in locally advanced cervical cancer ( P >0.05 ) .β-tubulinⅢexpression was correlated with efficiency and operation rate with TP chemotherapy but not with PF chemotherapy .Conclusions In the neoadju-vant chemotherapy of locally advanced cervical cancers ,β-tubulinⅢexpression can be used as an important index to predict the effec-tive rate of combined chemotherapy containing paclitaxel and guide the patients to individual chemotherapy .
