Application of immunohistochemistry in biopsy specimen for differential diagnosis of small cell lung carcinoma and non-small cell lung carcinoma
10.3760/cma.j.issn.1008-1372.2014.04.018
- VernacularTitle:免疫组化在肺小细胞癌和肺非小细胞癌活检标本中的鉴别诊断价值
- Author:
Lan DING
;
Chen YAO
;
Xia MEI
;
Lei GUAN
;
Chunguo JIANG
;
Yingchun WU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung/diagnosis;
Carcinoma,small cell/diagnosis;
Lung neoplasms/diagnosis;
Biopsy;
Diagnosis,differential;
Immunohistochemistry
- From:
Journal of Chinese Physician
2014;(4):488-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of immunohistochemistry in the differential diagnosis between small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC).Methods The protein expressions of CD56, Syn, TTF1, CK5/6, CK14, P63, CK7, and NapsinA in percutaneous lung biopsy and bronchoscopic biopsy specimens which were suspected as SCLC were examined by immunohistological streptavidin-peroxidase ( SP) method to analyze the pathological characteristics , immunological pheno-typical features , and differential diagnosis between SCLC and NSCLC .Results Among 72 cases of lung cancer patients ,there were 27 cases of SCLC,17 cases of low differentiated squamous cell carcinoma ( SCC) and 28 cases of low differentiated adenocarcinoma ( ADC) .Conclusions It is the different therapy between SCLC and NSCLC , immunohistochemistry analysis of biopsy can provide ac-curate diagnosis of SCLC and NSCLC , which will result in less misdiagnosis and provide an important valuable in the selection of clini -cal treatment protocols for lung cancer patients .
