Roles of B-cell receptor signaling and its targeted inhibitors in lymphoid malignancies
10.3969/j.issn.1001-1978.2014.05.003
- VernacularTitle:B细胞受体信号及其靶向抑制剂在恶性淋巴瘤中的作用
- Author:
Xing DAI
;
Xiaoyi JIA
;
Yujing WU
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
BCR signaling;
lymphoid malignancies;
Syk;
Btk;
PI3K;
targeted inhibitors
- From:
Chinese Pharmacological Bulletin
2014;(5):604-607
- CountryChina
- Language:Chinese
-
Abstract:
Lymphoma is a malignancy of mature lymphocytes. Signalling through the B cell receptor ( BCR ) is central to the development and maintenance of B cells. In light of the numer-ous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and survival. Compounds that inhibit various components of this pathway, in-cluding spleen tyrosine kinase(Syk), Bruton’s tyrosine kinase (Btk), and phosphoinositol-3 kinase(PI3K), have been devel-oped. In this paper,the B-cell receptor signaling and its targeted inhibitors of lymphoid malignancies are reviewed.
