BCRP-targeted reverse of multidrug resistance：research progress and drug development
10.3969/j.issn.1001-1978.2014.05.006
- VernacularTitle:靶向乳腺癌耐药蛋白逆转肿瘤耐药：研究进展与药物开发
- Author:
Cunzhi YU
;
Xinming QI
;
Jin REN
- Publication Type:Journal Article
- Keywords:
breast cancer resistance protein ( BCRP );
tumor multidrug resistance;
expression regulation;
subcellular localiza-tion;
energy dependence;
transport activity inhibition;
clinical drug strategy;
drug development
- From:
Chinese Pharmacological Bulletin
2014;(5):615-618
- CountryChina
- Language:Chinese
-
Abstract:
As an important ABC transporter, breast cancer re-sistance protein ( BCRP) plays an important role in tumor multi-drug resistance. Many laboratories are focusing on BCRP to re-verse multidrug resistance. We summarize in the paper the re-search progress on the regulation of BCRP expression, subcellu-lar localization, ATP-dependence, inhibition or modulation of its transport activity and potential clinical treatment strategies in or-der to provide theoretical support and some new research ideas for the reverse of multidrug resistance in clinic.
