Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child.
- Author:
Ki Won OH
1
;
Se Young KIM
;
Hwan Suk LEE
;
Myung Hoon LEE
;
Byung Ho CHOE
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. bhchoi@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Familial adenomatous polyposis;
NSAID;
COX-2 inhibitor;
Celecoxib
- MeSH:
Adenoma;
Adenomatous Polyposis Coli*;
Child*;
Colectomy;
Female;
Humans;
Polyps;
Sulindac;
Celecoxib
- From:Journal of the Korean Pediatric Society
2002;45(12):1591-1595
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.
