Changes of endogenous vascular elastase in Kawasaki diseases and its role in the pathogenesis of coronary artery le-sions
10.3969/j.issn.1000-3606.2014.04.006
- VernacularTitle:川崎病患儿内源性血管弹性蛋白酶变化及其与冠脉损伤的关系
- Author:
Yiling LIU
;
Xianmin WANG
;
Yan LI
;
Yonghong GUO
;
Yanfeng YANG
;
Kun SHI
;
Tingting CHEN
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
coronary artery lesion;
EVE;
MMP-9;
TGF-β1
- From:
Journal of Clinical Pediatrics
2014;(4):319-322
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential role of endogenous vascular elastase (EVE) in pathogenesis of coronary ar-tery lesions (CAL) in Kawasaki diseases (KD). Methods A total of 60 children with KD admitted from Jan. 2012 to Apr. 2013 were enrolled, and at the same time 60 febrile children with respiratory infection were enrolled as controls. The left and right coro-nary artery diameter value was measured by ultrasonic cardiogram. The levels of EVE, matrix metalloproteinases (MMP)-9 and transforming growth factor (TGF)-β1were determined by enzyme-linked immunosorbent assay and their correlations with coro-nary artery diameter were analyzed. Results The levels of EVE, MMP-9 and TGF-β1 in KD children in the acute phase were significantly higher than those in control group (P<0.01). Meanwhile, the level of EVE in KD children with coronary artery le-sion (CAL) is significantly higher than that in KD children without CAL. The results of correlation analysis indicated that the levels of EVE, MMP-9 and TGF-β1 were positively correlated with coronary artery diameters (r=0.64~0.79, P<0.01). Conclu-sions EVE plays an important role in the CAL of KD may through inducing the produce of MMP-9, TGF-β1 and finally caus-ing the formation of CAL.
