Effect of Clearing Heat and Resolving Phlegm on Blood Level of Neutrophil Elastase in AECOPD Rats
- VernacularTitle:清热化痰法对AECOPD大鼠血清中性粒细泡弹性蛋白酶水平的影响研究
- Author:
Jie LI
;
Qi WANG
;
Cuiling FENG
;
Lishan ZHANG
;
Zeji QIU
;
Jun WU
;
Hui LUO
;
Fenglan DONG
;
Fuding LIU
;
Fucheng ZHAO
;
Ying QI
;
Guangwei XUE
- Publication Type:Journal Article
- Keywords:
Clearing heat and resolving phlegm;
AECOPD rats;
Neutrophil elastase
- From:
China Pharmacist
2014;(5):722-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preliminarily study the effect of Louqin Zhisou decoctions with the mechanism of clearing heat and resol-ving phlegm on the blood level of neutrophil elastase ( NE) in the rat model of acute exacerbation of chronic obstructive pulmonary dis-ease ( AECOPD) . Methods:The rat model of AECOPD was established by passive cigarette smoking, intratracheal instillation of li-popolysacchricle ( LPY) and intranasal instillation of staphylococcus aureus. Totally 60 AECOPD rats were randomly divided into 3 groups, the model control group (n=20), ambrohexel group (n=20), and Louqin Zhisou decoctions group (n=20). NE was detec-ted by ELISA. Results:Compared with that before the treatment, NE in ambrohexel group and Louqin Zhisou decoctions group was de-creased significantly(P<0. 01). Conclusion:Clearing heat and resolving phlegm method probably can decrease NE by reducing air-way mucus hypersecretion and obstruction in AECOPD rats.
