Clear cell sarcoma of gastrointestinal tract：clinicopathologic analyses and review of litera-tures
10.13315/j.cnki.cjcep.2014.04.007
- VernacularTitle:胃肠道透明细胞肉瘤临床病理分析并文献复习
- Author:
Huifen HUANG
;
Qian LIU
;
Hong BU
;
Min CHEN
;
Huijiao CHEN
;
Yingying LIN
;
Hongying ZHANG
- Publication Type:Journal Article
- Keywords:
gastrointestinal neoplasms;
clear cell sarcoma of the gastrointestinal tract;
clear cell sarcoma like tumor of gastrointestinal tract;
clear cell sarcoma of soft tissue;
genetics
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(4):383-388
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the clinicopathologic and genetic features of clear cell sarcoma of the gastrointestinal tract. Methods One case of clear cell sarcoma of the gastrointestinal tract was analyzed by histology, immunohistochemistry, fluorescence in situ hy-bridization ( FISH) , with review of relevant literatures. Results A female patient was admitted to the hospital with a history of 1-week abdominal pain. Computed tomography revealed a mass in right hemicolon. A grey-white ulcerated mass was observed in the colon, in-volving the entire thickness of the colon wall extending into the subserosa. Microscopically, medium-size oval or round cells were ar-ranged in sheets and scattered osteoclast-like multinucleated giant cells were also presented. Immunohistochemically, the tumor cells were strongly positive for S-100 protein, but negative for HMB-45, Melan-A, CD117, CD1a and PCK. FISH showed the rearrangement of EWSR1 in 74% of the neoplasm cells. Conclusions Clear cell sarcoma of the gastrointestinal tract is an extraordinarily rare gastro-intestinal neoplasm that shows peculiar histopathological, immunohistochemical, ultrastructural, and genetic features. Whether clear cell sarcoma-like gastrointestinal tumor represents a distinct entity awaits larger series, including cytogenetic or molecular biological in-vestigation.
