Pathological characteristics of loco-regional recurrent nasopharyngeal carcinoma
10.13315/j.cnki.cjcep.2014.04.008
- VernacularTitle:局部复发性鼻咽癌的临床病理学特征
- Author:
Juanjuan YONG
;
Qiuliang WU
;
Yongsheng ZONG
;
Jinghui HOU
;
Jianzhong LIANG
;
Yaling KUANG
;
Shaoyan XI
;
Jiabin LU
- Publication Type:Journal Article
- Keywords:
nasopharynx neoplasms;
loco-regional recurrent nasopharyngeal carcinoma;
pathological characteristics;
immunohisto-chemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(4):389-392
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the pathological characteristics of loco-regional recurrent nasopharyngeal carcinoma ( rNPC ) . Methods Nasopharyngeal biopsy specimens of 46 rNPCs and 63 primary NPCs were collected. HE staining, immunohistochemistry and EBV small RNAs ( EBERs) in-situ hybridization were performed. Results The over-expression rates of both p63 and CK5/6 in rNPC were significantly higher than those of primary NPCs (P=0. 005, P=0. 026), while no statistical significance of Ki-67 over-ex-pression existed between the two groups ( P=0. 387 ) . More necrotic tissues, inflammatory exudates, giant bizarre carcinoma cells, desmoplastic stroma, giant bizarre tumor cells and higher degree of squamous differentiation were found in rNPCs. The carcinoma cells of 5 rNPCs were negative for both EBERs in-situ hybridization and LMP-1 immunohistochemical staining. Conclusion The loco-re-gional rNPC has two peaks of latency interval:2~5 and 9~11 years. The loco-regional rNPC cells have higher degree of squamous differentiation with higher expression of p63 and CK5/6, as well as more invasive ability. In addition, both EBERs in-situ hybridization and LMP-1 immunostaining are negative in 10. 87% (5/46) of loco-regional rNPC.
