Preliminary study on the inhibitory effect of salidroside on H22 ascites hepatoma
10.3969/j.issn.1001-1978.2014.05.022
- VernacularTitle:红景天苷对腹水型H22肝癌抑制作用及其机制的初步研究
- Author:
Xiaoxi HE
;
Shurong MO
- Publication Type:Journal Article
- Keywords:
salidroside;
H22;
tumor;
survival time;
immunity;
mechanism
- From:
Chinese Pharmacological Bulletin
2014;(5):688-691
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the inhibitory effect of salidroside on tumor growth in tumor-bearing mice and explore its possible mechanisms of anti-tumor action in vivo. Methods The tumor-bearing mice model was established, and the mice were randomly divided into five experimantal groups, including the salidroside low, medium and high doses groups, NS group and positive control matrine group. After continuous injec-tion of drug for eight days, the tumor growth and sur-vival time were measured, tumor growth inhibition rate and life extension rate, spleen index,the content of se-rum IL-2 and IL-12 were calculated. Results The general situation of the salidroside mice was better than the NS group and the positive control matrine group. Compared with NS group, the salidroside low,medium and high doses groups showed inhibitory effects on H22 solid tumor ( P<0. 01 ) with inhibition ratio 28. 9 %, 43. 3 % and 53. 5 %,and lengthened the survival time of mice ( P<0. 01 ) with the life extension rate 37. 54%,48. 96 % and 52. 85 % respectively. The spleen index and the content of serum IL-2 and IL-12 of the salidroside mice were significantly higher than NS group and matrine group. Conclusion Salidroside has marked inhibitory effects on tumor growth in vivo, its mechanism is probably related to improving the anti-tumor immune function.
