Study on the relationship between HLA-B * 5801 and severe cutaneous adverse reactions caused by allopurinol
10.3760/cma.j.issn.1007-7480.2014.04.010
- VernacularTitle:人类白细胞抗原B*5801与别嘌醇诱发重症药疹相关性研究
- Author:
Xinju ZHANG
;
Jiong ZHANG
;
Weizhe MA
;
Danqiu ZHOU
;
Ming GUAN
;
Hejian ZOU
- Publication Type:Journal Article
- Keywords:
HLA antigens;
Allopurinol;
Drug eruptions
- From:
Chinese Journal of Rheumatology
2014;18(4):259-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HLA-B * 5801 allele and severe cutaneous adverse reactions caused by allopurinol or other drugs.The clinical value of HLA-B * 5801 as the marker of allopurinol-SCAR was evaluated.Methods Forty-three patients with allopurinol-SCAR,133 patients without SCAR after taking allopurinol for 3 months were included.Ninety-six patients with SCAR caused by other drugs and 148 healthy individuals were enrolled into the present study.HLA-B * 5801 allele was detected by PCR-SSP method.Data were analyzed by chi-square test.Results HLA-B * 5801 was present in 40 of 43 (93.0％) patients with allopurinol-SCAR,which was significantly higher than 19 of 148 (12.8％) in healthy subjects (x2=100.353,P＜0.01,OR=90.5,95％CI 25.5-321.8).But there were no significant differences between allopurinol-tolerant patients and healthy controls(10 of 133,7.5,x2=2.141,P＞0.05,OR=0.6,95％CI 0.2-1.2).And there were only 14 of 96 (7.5％) patients with SCAR caused by other drugs had HLA-B * 5801 (x2=0.152,P＞0.05,OR=1.2,95％CI 0.6-2.4).Conclusion The study indicates that people with HLA-B * 5801 have a high risk of allopurinol-SCAR.HLA-B * 5801 is a specific and predictive marker for guiding the selection of uric acid lowing drug allopurinol.
