Relations between resistin and hepatic fibrosis in nonalcoholic fatty liver disease subjects
10.3760/cma.j.issn.1008-1372.2014.04.016
- VernacularTitle:非酒精性脂肪性肝病中抵抗素和肝纤维化的关系
- Author:
Peixian WU
;
Wei LAN
;
Fan ZHANG
;
Yali DAI
;
Xiaoyan XU
;
Donghui LU
;
Ningbo ZHANG
;
Yuan LIN
;
Qian XIE
- Publication Type:Journal Article
- Keywords:
Fatty liver/metabolism;
Resistin/blood;
Insulin resistance;
Liver cirrhosis
- From:
Journal of Chinese Physician
2014;(4):482-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between resistin and hepatic fibrosis in nonalcoholic fatty liver disease (NAFLD) subjects.Methods Serum resitin and Interleukin (IL)-18's concentrations were measured in 144 subjects (70 NAFLD pa-tients and 74 healthy controls) with enzyme-linked immunosorbent assay (ELISA) and their serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting blood glucose (FBG), HbA1c, triglyceride (TG), total-cholesterol (TC), low density lip-oprotein ( LDL) , high density lipoprotein ( HDL) , homeostasis model assessment of insulin resistance ( HOMA-IR) , hyaluronic acid , IVcollagen, height, body weight, waist circumference, and hip circumference were also measured .Their waist-to-hip ratio (WHR) and body mass indes (BMI) were calculated.Results There were higher levels of systolic blood pressure (SBP), WHR, BMI, TG, ALT, AST, HOMA-IR, hyaluronic acid, IV collagen, resistin, and IL-18 in the NAFLD patients than those of the healthy controls ( P <0.05 ) .The serum resistin level was significantly and positively correlated with WHR , BMI, ALT, HOMA-IR, TG, IV collagen , and IL-18 ( r =0.231 , 0.341 , 0.223 , 0.264 , 0.213 , 0.315 , and 0.669 , P <0.05 ) .After adjustment for body fat and IL-18 , the serum resistin level was still significantly and positively correlated with ALT and IV collagen ( r =0.222 , 0.0.326 , P <0.05 ) . Conclusions Resistin might take part in the development of NAFLD insulin resistance and its pro -inflammation.
