Research progress of autophagy and tumor stem cells
10.3760/cma.j.issn.1673-422X.2014.04.003
- VernacularTitle:自噬与肿瘤干细胞的研究进展
- Author:
Lulu ZHANG
;
Yueying ZHANG
;
Weidong ZHANG
- Publication Type:Journal Article
- Keywords:
Autophagy;
Neoplastic stem cells;
Neoplasms
- From:
Journal of International Oncology
2014;41(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Cell autophagy is a lysosome dependent degradation pathway which is characterized by cytoplasm vacuoles.It is important to maintain cell internal environment.The abnormal autophagy is associated with oncogenesis closely.The tumor stem cells which rarely exist in tumor tissues have stem cell properties.They can induce tumor generation and also play an important role in the development,metastasis and recurrence of tumor.The regulation of autophagy in tumor stem cells is the research hotspot,which will provide a new theoretical foundation for the clinical treatment of tumors.
