Effects of Antipsychotics on the Inflammatory Response System of Patients with Schizophrenia in Peripheral Blood Mononuclear Cell Cultures.
- Author:
Md Mamun AL-AMIN
1
;
Mir Muhammad NASIR UDDIN
;
Hasan MAHMUD REZA
Author Information
1. Department of Pharmacy, North South University, Dhaka, Bangladesh. alamin@northsouth.edu
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Cytokines;
Antipsychotic;
Lipopolysaccharides
- MeSH:
Antipsychotic Agents*;
Cell Culture Techniques*;
Clozapine;
Cytokines;
Haloperidol;
Humans;
Interleukin-10;
Interleukin-4;
Lipopolysaccharides;
Risperidone;
Schizophrenia*;
Quetiapine Fumarate
- From:Clinical Psychopharmacology and Neuroscience
2013;11(3):144-151
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We investigated the effects of antipsychotics on immune-challenged peripheral blood mononuclear cell (PBMC) cultures. METHODS: Blood samples were collected from twelve patients with first-episode schizophrenia. The PBMCs were separated and cultures were prepared and stimulated with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly[I:C]), and then separately treated with a typical antipsychotic (haloperidol) or atypical antipsychotic (clozapine, quetiapine, or risperidone). Pro-inflammatory (interferon gamma [IFN-gamma]) and anti-inflammatory (interleukin [IL]-4 and IL-10) cytokine levels were measured in the LPS- or poly(I:C)-stimulated PBMC cultures treated with antipsychotics. RESULTS: Haloperidol and quetiapine significantly increased the IL-4 levels (p<0.05) in LPS-stimulated PBMC cultures, while clozapine and quetiapine significantly enhanced the IL-4 levels (p<0.05) in poly(I:C)-stimulated PBMC cultures. Only treatment with haloperidol resulted in a significant increase in IL-10 production (p<0.05) in LPS-stimulated PBMC cultures, whereas clozapine, quetiapine, and risperidone treatment significantly increased IL-10 production (p<0.05) in poly(I:C)-stimulated PBMC cultures. All of the antipsychotics reduced the IFN-gamma level significantly (p<0.05) in LPS- and poly(I:C)-stimulated PBMC cultures. CONCLUSION: Antipsychotic treatment altered immune function by raising the levels of anti-inflammatory cytokines (IL-4 and IL-10) and suppressing the levels of pro-inflammatory cytokines (IFN-gamma).
