Polymorphism of SMAD7 and susceptibility to non-small cell lung cancer

VernacularTitle:SMAD7基因多态性与非小细胞肺癌易感性的相关性研究
Author: Ping FU ; Fuxia WANG ; Lixian CUI ; Bin CUI ; Jie LIU
Publication Type:Journal Article
Keywords: Polymorphism,single nucleotide; Smoking; Carcinoma,non-small-cell lung; Disease susceptibility; SMAD7
From: Journal of International Oncology 2014;41(5):383-386
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between single nucleotide polymorphisms (rs12953-717) of SMAD7 and susceptibility of non-small cell lung cancer (NSCLC) in Chinese Han population.Methods A single nucleotide polymorphisms (rs12953717) from SMAD7 was detected via Sequenom system in 528 NSCLC cases and 762 healthy controls.Data was statistically analyzed by unconditional Logistic regression method.Results rs12953717 had significant differences between non-small cell lung cancer patients and the controls.Compared with CC/TT (CC combined with TT) genotype,the adjusted odds ratio for the CT genotype was 4.107 (95％ CI:3.206 ～ 5.260,P =0.000 1).Smokers had a 2.004 odds ratio (95 ％ CI =1.583 ～ 2.537,P =0.000 1) of NSCLC compared with the controls.There was a 10.074-fold increased risk of NSCLC among the subjects with CT genotype and smokers.Conclusion The polymorphism of rs12953717 may have relation with risk of NSCLC.Heterozygote (CT) is a susceptibility genotype of NSCLC.Smoking is one of the risk factors of NSCLC.Smoking and CT genotype have synergistic effects on NSCLC susceptibility.