cAMP signaling pathway and multiple myeloma
10.3760/cma.j.issn.1673-422X.2014.05.015
- VernacularTitle:cAMP信号通路与多发性骨髓瘤
- Author:
Yingying WANG
;
Qi ZHU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Cyclic AMP;
Apoptosis
- From:
Journal of International Oncology
2014;41(5):368-370
- CountryChina
- Language:Chinese
-
Abstract:
The clonal proliferations of multiple myeloma cells consist of several signaling pathways.It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway,an important intra-cellular messenger delivery system,is related to abnormal proliferation and apoptosis of malignant lymphoid cells including myeloma cells.Manipulating the cAMP signaling pathway could induce cell cycle arrest and apoptosis of various malignant lymphoid cells including myeloma cells,which involve mitochondrial-dependent apoptosis and cAMP-modulated changes of intra-cellular mediators.In-depth researches and analysis of cAMP-induced apoptosis in myeloma cells would provide potential targets and possible therapeutic means in the treatment of multiple myeloma.
