Human 8-oxoguanine DNA glycosylase and lung cancer
10.3760/cma.j.issn.1673-422X.2014.05.007
- VernacularTitle:人8-羟基鸟嘌呤DNA糖苷酶1与肺癌
- Author:
Liu BIN
;
Ziying LIN
;
Lawei YANG
;
Gang LIU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
DNA,mitochondrial;
hOGG1
- From:
Journal of International Oncology
2014;41(5):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Dysfunction of the human 8-oxoguanine DNA glycosylase (hOGG1) is closely related to development of lung neoplasms and other cancers.Polymorphisms in hOGG1 gene may alter glycosylase activity,thereby affect its repair capacity to the damaged DNA,contributing to carcinogenesis.Joint effects of hOGG1 and other DNA repair gene SNPs have showed complex gene-gene interactions may significantly contribute to people's lung cancer susceptibility.HOGG1 plays an important role in maintaining mitochondrial respiration thus affects tumor cell growth.
